Organic Chemistry · Vol. 9, Issue 2 · pp. 760–773

Reaction Time and Yield in 449 Green Solvent Synthesis Trials

Villy Damm · Lavinia Loska · Alessio Kühnert

Stanford University · Caltech · Thomas Jefferson High School for Science and Technology

Abstract

This study revisits green solvent synthesis through the lens of low-cost analysis. We assemble a dataset of 1401 observations and evaluate three competing models under matched conditions. The proposed approach improves on the strongest baseline by 23% while reducing computational cost. We discuss limitations and outline directions for follow-up work at the undergraduate level.